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INTRODUCING PRIMILUNGS™ AND THE HEALTH BENEFITS 

Edward E. Jacobs, Jr, MD (Dr Ted), a graduate of Princeton and Harvard Medical School, is a biotechnology consultant with over 25 years experience in biopharmaceutical and medical device development, as well as, 35 years of teaching and direct patient care. His drug development experience has involved international human and animal trials, including medical support for the FDA and global regulatory affairs. Dr. Jacobs received surgical training at Harvard and held research positions at the National Heart, Lung and Blood Institute, Bethesda, MD, and at St. Thomas’ Hospital Medical School, London. He has served as an Assistant Clinical Professor at Harvard Medical School, on the Scientific Advisory Board of the Armenise-Harvard Foundation and the Publications Committee for the New England Journal of Medicine. His current focus is on natural supplement formulations for human and animal use, anti-aging strategies, and primitive cell biology. He is an author of more than 40 scientific publications and is the holder of four patents.

primilung-1bottle

PrimiLungs™: Dietary Supplement for Lung and Immune Support

Several natural ingredients are known to strengthen the immune system and to support healthy breathing. The ingredients are well documented, but the difficulty can be in choosing which ones to take.

Thankfully, that work has already been done for you.

 

PrimiLungs is a formulation of all-natural botanical ingredients designed to

Boost Immune System Defense

and

Promote the Lung’s Natural Resistance to Stress

PrimiLungs™ is an all-natural supplement consisting of a derivative blend of ingredients tested and utilized in humans and animals for the past five years where safety and efficacy were systematically demonstrated.  No adverse effects have been observed or reported during testing, or by consumers, veterinarians, or health care providers.

 

Reported Effects in Humans

Generally, people notice an improvement within 1 to 2 weeks after consuming PrimiLungs™ on a daily basis. The majority of users experience a higher energy level, less fatigue, faster recovery from exercise, accelerated wound healing and elevation of mood.  Increased hair and nail growth and improved hair and nail quality are also frequently reported. These effects are believed to be related, not only to the direct activity of the components in PrimiLungs™, but also to the activation of various primitive cells.  Primitive cells, including stem cells and their derivatives, are found in the bone marrow and in every organ of the body. They act like a factory to produce immune cells and whatever specialized cells are needed to repair organs like the LUNGS, HEART and LIVER.

Reported Effects in Animals:

The ingredients found in PrimiLungs™ and derivative formulations have also been studied in horses and dogs where similar beneficial effects were seen.

Reported Effects in Horses

Performance horses were noted to have more energy, run faster, recover more quickly from extreme exercise and from fatigue related to being transported. In addition, they displayed accelerated wound healing, improved sleep patterns, greater manageability, and improved hair and hoof quality and growth.

Importantly, performance horses were perceived to have an increased resistance to Lung damage (bleeding) when stressed by extreme exercise. Exercise Induced Pulmonary Hemorrhage (EIPH) is a common condition seen in performance horses and it has also been seen in human athletes and greyhounds. The exact cause of EIPH is unknown but it is thought that Lung abnormal blood flow and excessive inflammation could be factors.  Gynostemma, a natural adaptogenic supplement in PrimiLungs™, has been used for many years to regulate blood flow and help control  Lung Inflammation.

Reported Effects in Dogs

Dogs were noted to have more energy (like a puppy), run faster, and recover more quickly from extreme exercise and from fatigue related to being transported. In addition, they displayed accelerated wound healing, improved sleep patterns, greater manageability, and improved hair and claws quality and growth.

 

Dogs, especially aging animals, of many breeds have shown a remarkable rejuvenation effect in addition to the benefits seen in horses.  This effect, observed by owners and veterinarians, usually occurs within one week and is shown as a definite increase in energy, mobility, and cognition.

Here’s How PrimiLungs™ Can Help Strengthen Your Lungs and Immune System

PrimiLungs™ all-natural formula is designed to support healthy, functioning lungs and a strong immune system. Healthy lungs are necessary to maintain an adequate and continuous OXYGEN supply for the brain, heart, liver, kidneys, and other vital organs.

PrimiLungs helps the immune system to give critical protection for the lungs and other vital organs. The immune system detects and destroys harmful threats like viruses, bacteria, abnormal cells, and toxic substances.

PrimiLungs activates primitive cells that replace damaged cellular components of the immune system, lungs, and all other organs.

PrimiLungs™ contains 62 minerals and trace minerals, 18 amino acids, 10 vitamins, and 14 fatty acids including omega 3,5,6,7. It is gluten free, has no trans-fat, no cholesterol, no added sugar, and is non-GMO.

  • Increases Lung Resistance to Damage and Stress
  • Provides Immune System Support
  • Naturally Increases the Activity of Your Own Regenerative Primitive Cells
  • Provides Anti-inflammatory and Antioxidant Support
  • Alleviates Depressive Mood
  • Enhances Physical Performance, Recovery and Endurance

PrimiLungs™ is composed of:

 

• AFA (Aphanizomenon Flos-Aquae , Blue-Green Algae)

Aphanizomenon Flos-Aquae –  a species of cyanobacteria (blue-green algae) – grows naturally in fresh water lakes and has been sold in the United States as a dietary supplement since the 1980s.

Aphanizomenon Flos-Aquae (AFA) is known to contain nutrients, including essential fatty acids, active enzymes, vitamins, amino acids, minerals, proteins, complex carbohydrates, and phytochemicals, and is marketed as a nutritional supplement. Consumers report increased energy, better hair and nail growth, improved wound healing and recovery from exercise, and elevation of mood.

An ethanol extract of AFA-cellular concentrate has been shown to increase stem cell proliferative action when incubated with human adult bone marrow cells or human CD34+ hematopoietic progenitors in culture. The preliminary study suggests that the ethanol extract of AFA cellular concentrate may act to promote proliferation of human stem cell populations.9

• Spirulina (Aphrospira platensis, Blue Green Algae)

Spirulina ( Arthrospira sp.), a spiral shaped cyanobacterium, classified as a blue-green microalgae, grows naturally in alkaline lakes and is commercially cultivated as a food source and natural supplement for humans and animals. It is nutrient rich, containing protein, all essential amino acids, vitamins and minerals. Importantly, spirulina is a significant source of omega acids (gamma-linoleic, palmitoleic, oleic) and carotenoids, including beta-carotene and phycocyanin.

An important component of spirulina is a protein-bound photosynthetic pigment called C-Phycocyanin, which has demonstrated anti-inflammatory, antioxidant, antitumor, and immune-stimulating properties. 34These effects are due, in part, to the phycocyanobilin constituent of C-Phycocyanin, similar to human bilirubin that functions to inhibit NADPH oxidase activity4,5

An anti-diabetic benefit of spirulina’s NAPDH oxidase inhibition is the decrease in the lipotoxic destruction of insulin producing pancreatic beta cells. The oxidative destruction of beta cells is thought to be involved in the occurrence of diabetes38

Numerous studies indicate that spirulina can contribute to the maintenance of good health especially related to aging. The phycocyanin in spirulina, a powerful antioxidant, helps to mitigate the harmful effects of oxygen radicals thought to play a central role in the aging process. In a double blindi placebo controlled study of aging Koreans, there was a significant reduction of inflammatory cytokines. Also, a reduction of serum triglycerides found in this study was confirmed in a second clinical trial in a Mexican population which additionally resulted in a decrease in cholesterol and blood pressure. 39,40

There is evidence, based on laboratory studies in rats, that spirulina can prevent mineral toxicity. The offspring of pregnant rats given fluoride, were protected from fluoride poisoning and the neural tissue of young rats had a significant reduction in lead accumulation. 36 Further, reduction of cadmium levels have been shown in the pups of pregnant rats have been noted as well.37

• Rhodiola Rosea (root) extract [std. to 4% rosavins, 4% salidrosides]

Rhodioloa Rosea has been an important natural supplement in Russia and Europe for several hundred years. Traditionally, it has been used as an adaptogen to increase resistance to physical and mental stress being employed to manage a variety of health issues such as fatigue, depression, anemia, impotence, gastrointestinal ailments, infections, and nervous system disorders. More recently, Extracts of Rhodiola rosea have been administered to athletes to improve performance, build muscle mass, and increase endurance. Extensive research, establishing the safety and efficacy, has been conducted primarily in Russia and Scandinavia.

The main active chemicals in Rhodiola rosea, salidroside and rosavins, are thought to be responsible for the improvement in mental and physical performance and management of fatigue seen in clinical studies involving physicians, students and athletes. Animal studies suggest that Rhodiola rosea is an anti-oxidant and may increase essential energy metabolites, adenosine triphosphate (ATP) and creatine phosphate in muscle and brain mitochondria. In addition, studies indicate that there are cardio protective effects, including prevention of stress induced cardiac damage and reperfusion arrhythmias. 10,11

The cardio-protective effects (related to in vitro heart tissue)appears to be due to anti-oxidative action of the active compounds (tyrosol and salidroside)18

Also, a neuro-protective effect has been observed, demonstrated on isolated neurons, believed to be related to inducement of anti-oxidative enzymes 19 

Multiple studies indicate that daily supplementation with Rhodiola rosea improves stamina, increases resistance to fatigue and the associated impairment of cognition especially noted in average, healthy people engaged in routine activities20,21

General depressive mood has been noted to improve with daily Rhodiola rosea supplementation. This effect appears to be significant, however, the mechanism is not understood24.

Anti-aging studies conducted in the laboratory, utilizing nematode worms ( C. Elegans) and fruit flies (Drosophila), demonstrate a significant prolongation of lifespan (i.e. 20-24%) in these models. The effect is thought to be due to the active molecules, salidroside and rosavins25,26 The highest available concentration of salidroside (4%) and rosavins (4%) available in Rhodiola rosea is utilized in the PrimiCell@ formulation.

• Cordycep Prime, a Cordycep Sinesis (mycelium) extract [std. to 8% cordycepic acid]

Cordyceps (Cordyceps Sinensis) is a fungus that has been used as an herbal medicine for many centuries in China.  The scarce wild form has been supplemented by cultivated  production since the 1980s.  Cordyceps, a potent antioxidant and anti-inflammatory agent, is valued for its broad biological and pharmacological actions in immunological, hepatic, renal, and cardiovascular systems.   In addition, there is evidence that Cordyceps enhances cellular energy in the form of ATP (adenosine tri-phosphate).14,15

The overall effect of Cordyceps is to increase vitality and well-being by supporting energy production and improved cardiovascular and exercise performance.  In addition, there is an expected antioxidant and anti-inflammatory effect manifested by anti-bacterial, anti-fungal, anti-viral and anti-cancer activity.

The antitumor effect of Cordyceps, may be due to multiple mechanisms, including direct cytotoxicity, immunopotentiation, apoptosis, selective inhibition of ribonucleic acid (RNA), and protein synthesis, as well as antioxidant, antiangiogenic, antimutagenic, antimetastatic, and antiviral activities.32,33,34

Cordyceps, an adaptogen, exhibits bidirectional modulation activity with both potentiating and suppressive effects on the immune system through regulating innate and adaptive immunity.  The dominant adaptogenic effect supports survival and depends upon the biochemical circumstances.35,36

The hypoglycemic activity of Cordyceps has been shown in normal animals administered a Cordyceps carbohydrate extract for 25 days. This study in rats resulted in increased insulin sensitivity and the maintenance of whole-body glucose disposal with a less-pronounced increase in insulin secretion after a carbohydrate challenge.29

In another study, fermented mycelia and broth of Cordyceps Sinensis produced similar anti-hyperglycemic effects in diabetic rats.30  This observation has led to the speculation that fermented products of Cordyceps could be developed as potential anti-diabetic agents or functional foods for persons with a high risk of diabetes mellitus.

• Astragin® (Astragalus membranaceus (root) extract and Panax notoginseng (root) extract)

AstraGin® is a proprietary blend of highly purified extracts from astragalus membranaceus and panax notoginseng that has undergone extensive investigation for more than a decade to establish its safety and efficacy.  In multiple in vitro and in vivo studies, AstraGin® has been shown to significantly increase the intestinal absorption of amino acids, including arginine, agmatine, beta-alanine, citrulline, creatine, leucine, peptides and tryptophan.  Also, there was a demonstrated increase in the absorption of glucosamine, folate, curcumin, polyunsaturated fatty acid and omega 7 (palmitoleic) acid.  AstraGin® increases the activity of nutrient transporter proteins that regulate the amount of amino acids, vitamins and other nutrients entering the intestinal cells to be carried in the circulation to the liver and the rest of the body. AstraGin®  has received the official designation of GRAS (Generally Regarded As Safe).

The importance of intestinal absorption is underscored by the fact that the benefit of nutrients depends not only on consumption of an effective amount into the stomach and intestinal tract but also on how much can be absorbed so that it becomes bioavailable in the bloodstream.  Because of the central effect of AstraGin®, there is an expected positive uptake of many nutrients. 16,17 

• Gynostemma (Jiaogulan)

Gynostemma (Gynostemma pentphyllum), also called jaogulan, a plant that grows in China and other parts of Asia, is known as the “immortality” herb because of its anti-aging and other health benefits. Its properties are similar, but more superior to ginseng since it displays adaptogenic features and is an antioxidant botanical with abundant saponins similar to those found in ginseng, trace minerals, amino acids, proteins and vitamins.

The saponins have a powerful regulatory effect on blood pressure, the reproductive, digestive, and immune systems and mental function. Importantly, this herb is also known to lower cholesterol and help balance the lipid profile.

Clinically, the overall effect is to protect against stress, strengthen the immune system, improve exercise performance and hasten recovery after exercise.

References:
  1. Rossi, D, Bryder, D, and Weissman, I.  Hematopoietic Stem Cell Aging: Mechanism and Consequence. Exp. Gerontol. (2007b) 42, 385–390.
  2. Sanz, A, Stefanatos, R.  The Mitochondrial Free Radical Theory of Aging: a Critical View. Curr Aging Sci. (2008) Mar;1(1):10-21
  3. Fuchs, E.  Finding One’s Niche in the Skin. Cell Stem Cell (2009) 4(6):499-502 
  4. Dranovsky, A, Picchini, A, Moadel, T, Sisti, A,Yamada, A, Kimura, S, Leonardo, E, Hen, R. Experience Dictates Stem Cell Fate in the Adult Hippocampus. 
  5. https://doi.org/10.1016/j.neuron.2011.05.022 Kucia M1Zuba-Surma EWysoczynski MDobrowolska HReca RRatajczak JRatajczak MZ. Physiological and pathological consequences of identification of very small embryonic like (VSEL) stem cells in adult bone marrow. J Physiol Pharmacol. 2006 Nov;57 Suppl 5:5-18.
  6. Bachstetter, A.D., et. al. Spirulina Promotes Stem Cell Genesis and Protects against LPS Induced Declines in Neural Stem Cell Proliferation. PLoS ONE 5(5):e10496 · May 2010 with 302 
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  8. Schroeder, P., Hertel, I., Schneider, M.,  Krutmann, J.:  The Effect of Processed Water on Constitutive and Ultraviolet-A-Radiation-Induced Level of Mitochondrial DNA Mutations in Human Dermal Fibroblasts:   Skin Pharmacol Physiol 2007;20:116–119 DOI: 10.1159/00009798
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  11. Maimeskulova, L.; Maslov, L.; Lishmanov, I.; Krasnov, E.;The participation of the mu-, delta-, kappa- opiod receptorsin the realization of the anti-arrhythmic effect of Rhodiola rosea  Eksp Klin Farmikol 1997: 60(1) 38-39
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